Patients with thrombocytopenia require lower doses correlating to reduced efficacy or are ineligible for ruxolitinib treatment if they have severe thrombocytopenia.A brief history of CTIC with a comment on current managementCTIC, previously known as Cell Therapeutics, was founded in 1991 in Seattle.

The founder and previous CEO was criticized for a managerial style that was not shareholder friendly and, therefore, was eventually replaced but not before some voiced their non positive opinion of him.

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